If you are interested in our research or want to join the lab, please feel free to contact us. This is not a link-free page. Please do not link without permission. Please send your inquiry about this home page, if any, by mail to the following address.

Tokyo Gakugei University FERJANI ALI Lab.

Greeting

We use forward and reverse genetic approaches to elucidate the logics of plant development, with a special emphasis on "COMPENSATION", a phenomena whereby cell size compensate for cell division in establishment of leaf size. In particular, we focus on the fugu series of mutants (fugu1~fugu5) and others in our laboratory.

We have established close collaborations with scientists in other research groups both within and outside Japan.
We have launched this homepage to share with you our excitement about new discoveries, research activities and interests, and to keep you informed about the opportunities to join our laboratory or to collaborate with us.

 

News

My graduate student Kazuki Takahashi (Master course) won the Prize of Tokyo Gakugei University president for his excellent research achievements. The awarding ceremony was held at Tokyo Gakugei University president’s office on March 17th, 2017. Congratulations!

Kazuki Takahashi (left) with the president of Tokyo Gakugei Univ. Prof. Toshisada Deguchi (right).

My student Kazuki Takahashi (Master course) won the Best Poster Award during the 28th Annual meeting of the Japanese Society of Plant Morphology, as a representative winner on behalf of his co-authors (Shizuka Gunji, Gorou Horiguchi, Hirokazu Tsukaya and Ali Ferjani). The awarding ceremony was held at Ryukyu Univ., Okinawa on September 15th, 2016.

(Left photo) Kazuki Takahashi (right) with his supervisor Ali Ferjani (left).
(Right photo) Kazuki Takahashi (right) receiving the best poster prize from Prof. Shigeyuki Kawano, the president of the Japanese Society of Plant Morphology (left).

The traditional annual joint seminar of Tsukaya lab. (The Univ. of Tokyo), Horiguchi Lab. (Rikkyo Univ.), Kawade Lab. (NIBB, OIB projects), Sakakibara Lab. (Rikkyo Univ.), and Ferjani Lab. (Tokyo Gakugei Univ.), was held on Aug-29-30, 2016, at Tokyo Gakugei Univ. (Koganei campus).

Joint seminar group photo of Tsukaya lab. (The Univ. of Tokyo), Horiguchi Lab. (Rikkyo Univ.) and Ferjani Lab. (Gakugei Univ.).

Our editorial paper“Editorial: Multiple facets of H+-pyrophosphatase and related enzymes.” has been accepted for publication in Frontiers in Plant Science on 9-Aug-2016

http://journal.frontiersin.org/article/10.3389/fpls.2016.01265/full

In collaboration with Prof. Feng QIN and her team at the IB-CAS, our paper entitled “Genetic variation in ZmVPP1 contributes to drought tolerance in maize seedlings” was published in the latest issue of Nature Genetics on 15 Aug., 2016 (doi: 10.1038/ng.3636).

http://www.nature.com/ng/journal/v48/n10/full/ng.3636.html

In collaboration with Prof. Masayoshi Maeshima and his team at Nagoya Univ. our paper entitled “Lack of H+-pyrophosphatase prompts developmental damage in Arabidopsis leaves on ammonia-free culture medium”, has been accepted for publication in Frontiers in Plant Science on 25-May-2016

http://journal.frontiersin.org/article/10.3389/fpls.2016.00819/full

Postdoctoral Position Tokyo Gakugei Univ. Depart. of Biology.

 A postdoctoral position is available to study the role of H+-PPase in plant development using Arabidopsis thaliana as a model system. A successful candidate should have a Ph.D. in Developmental Biology; Developmental Genetics; Molecular Biology; Biochemistry; or related fields, and a good publication record in plant science related research. A strong background in molecular biology with particular emphasis on gene cloning and transgenic line construction is desirable. The Ferjani lab studies many aspects related to Arabidopsis organogenesis, and we provide a fun and collaborative work environment. More information about the laboratory can be found at http://www.ferjani-ali.jp/. Highly motivated and interested candidates should submit their CV together with a cover letter indicating their area of scientific expertise, a brief statement of past and future research interests, and the names and contact information of two references to Ali FERJANI, PhD, Department of Biology, Tokyo Gakugei University, Nukui Kitamachi 4-1-1, Koganei-shi, Tokyo 184-8501. For any further details please contact Ali FERJANI at .

Dr. Mariko Asaoka joined our laboratory since 2016.4.1, as a PostDoc.

My undergraduate student Mao Ooe won the Prize of Tokyo Gakugei University president as the highest GPA score holder during her 4-year undergraduate studies. The awarding ceremony was held at Tokyo Gakugei University president's office on March 18th, 2016.

Mao Ooe (left) with her supervisor Ali Ferjani (right).

Our manuscript entitled "Contribution of PPi-hydrolyzing function of vacuolar H+-pyrophosphatase in vegetative growth of Arabidopsis: Evidenced by expression of uncoupling mutated enzymes", has been accepted for publication in Fronters in Plant Science on 17-Mar-2016

http://journal.frontiersin.org/article/10.3389/fpls.2016.00415/full

Our manuscript entitled "Suppressor screen and phenotype analyses revealed an emerging role of the Monofunctional peroxisomal enoyl-CoA hydratase 2 in compensated cell enlargement", has been accepted for publication in Frontiers in Plant Science on 25-Jan-2016

http://journal.frontiersin.org/article/10.3389/fpls.2016.00132/full

Multidimensional Exploration of Logics of Plant Development / Annual Metabolomics Meeting was held on 13-15-Feb-2016 at the Tsuruoka Metabolome Cluster/ Tsuruoka Metabolome Campus.

Group photo of meeting attendees (left) and oral session for progress reports and guest speakers (right)

Our manuscript entitled " A Decrease in Ambient Temperature Induces Post-Mitotic Enlargement of Palisade Cell in North American Lake Cress ", has been accepted for publication in PLOS ONE on 5-Oct-2013.

Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141247
Press Release (link): http://www.kyoto-su.ac.jp/department/nls/news/20151116_news.html

The annual joint seminar of Tsukaya lab. (The University of Tokyo), Horiguchi Lab. (Rikkyo University) and Ferjani Lab. (Tokyo Gakugei University) was held on September 17-18, 2015, at The Rikkyo University (Ikebukuro campus).

Joint seminar group photo of Tsukaya lab. (The Univ. of Tokyo), Horiguchi Lab. (Rikkyo Univ.) and Ferjani Lab. (Gakugei Univ.).

My undergraduate student Shizuka Gunji won the Prize of Tokyo Gakugei University president for her excellent research activities. The awarding ceremony was held at Tokyo Gakugei University president's office on March 20th, 2015.

Shizuka Gunji (in the middle) with the president of Tokyo Gakugei Univ. Prof. Toshisada Deguchi (left),
and her supervisor Ali Ferjani (right). The photograph is a Courtesy of "TGU Public Relations Planning Publicist Division".

My undergraduate student's work (Maeda et al. (2014) Plant Cell Physiol. 55:1994-2007) has been featured for the cover design of the November issue.

The cover shows a scanning electron microscopy image of a cracked stem of a clv3 det3-1 double mutant (Courtesy of Ali Ferjani and Shizuka Gunji, Tokyo Gakugei University, Japan).
This article and image are published with permission from Japanese Society of Plant Physiologists, and Oxford University Press. Plant and Cell Physiology http://pcp.oxfordjournals.org/

On Oct. 10th, 2014, and following the kind invitation of Drs. Tomomichi Fujita and Kensuke Kawade (Hokkaido University), we gave two seminars covering our recent progress about the roles of H+-PPase in the regulation of both plant metabolism and development (see titles and links below).

  1. Pyrophosphate hydrolysis by the vacuolar H+-PPase promotes gluconeogenesis in germinating oilseeds
    Ali Ferjani
    Link: http://ferjani-ali.jp/dl/141016_01.pdf
  2. Excessive pyrophosphate severely restrains the development of all epidermal cell types
    Shizuka Gunji, Hirokazu Tsukaya , and Ali Ferjani
    Link: http://ferjani-ali.jp/dl/141016_02.pdf

Best Poster Award
The 38th Naito Conference "Molecule-based biological systems"

The Best Poster Award was presented to Dr. Ali Ferjani (Associate Professor, Tokyo Gakugei University, Department of Biology) during the 38th Naito Conference, as a winning representative on behalf of his co-authors. The Naito Conference called for poster presentations that fit with the conference theme "Molecule-based biological systems". 60 posters have been approved by the organizing committee to be presented at the 38th Naito Conference. Among the 60 presenters, 10 scientists were selected as the winners of the Best Poster Award, and received a grant-in-aid of 500,000 Japanese Yen. The awarding ceremony was held at CHÂTERAISÉ Gateaux Kingdom SAPPORO on October 10th, 2014.

Awarded poster: Ali Ferjani, Kensuke Kawade, Akira Oikawa, Mariko Asaoka, Kazuki Takahashi, Masanori Ishida, Masayoshi Maeshima, Masami Yokota Hirai, Kazuki Saito and Hirokazu Tsukaya: The metabolic target of pyrophosphate inhibition, the enigmatic molecule in plant metabolism, unraveled.

The annual joint seminar of Tsukaya lab. (The University of Tokyo), Horiguchi Lab. (Rikkyo University) and Ferjani Lab. (Tokyo Gakugei University) was held on September 3-5, 2014, at The University of Tokyo (Hongo campus).

Joint seminar group photo of Tsukaya lab. (The Univ. of Tokyo), Horiguchi Lab. (Rikkyo Univ.) and Ferjani Lab. (Gakugei Univ.). The photograph is a Courtesy of Mr. Koro Hattori.

Our manuscript entitled " The Conflict between Cell Proliferation and Expansion Primarily Affects Stem Organogenesis in Arabidopsis", has been accepted for publication in Plant and Cell Physiology on 18-Sep-2014.

Link: http://pcp.oxfordjournals.org/cgi/content/abstract/pcu131?
ijkey=63WIpmqTh080e7u&keytype=ref

Two abstracts from our lab were selected for short talks in the forthcoming 25th International Conference on Arabidopsis Research (ICAR 2014). ICAR 2014 will be held at the University of British Columbia in Vancouver, Canada from Monday July 28th to Friday August 1st. See you all soon in Vancouver!

  1. The execution of developmental programs in all epidermal cell types are restrained by PPi overaccumulation
    Shizuka Gunji, Hirokazu Tsukaya, and Ali Ferjani
  2. The metabolic target of pyrophosphate, a mysterious player in plant metabolism, identified
    Ali Ferjani, Kensuke Kawade, Akira Oikawa, Mariko Asaoka, Kazuki Takahashi, Masanori Ishida, Masayoshi Maeshima, Masami Yokota Hirai, Kazuki Saito and Hirokazu Tsukaya

Impact of excess pyrophosphate on plant metabolism and development: New functions of an old player

Tomorrow, May 14th , 2014, and following the kind invitation of Dr. Keisuke Kimura (Kyoto Sangyo University) , I will give a seminar covering our recent progress about the roles of H+-PPase in the regulation of plant metabolism and development (see title above).

Link: http://www.kyoto-su.ac.jp/department/nls/news/20140514_seminar.html

Impact of excess pyrophosphate on plant metabolism and development: New functions of an old player

Tomorrow, May 14th , 2014, and following the kind invitation of Dr. Keisuke Kimura (Kyoto Sangyo University) , I will give a seminar covering our recent progress about the roles of H+-PPase in the regulation of plant metabolism and development (see title above).

Link: http://www.kyoto-su.ac.jp/department/nls/news/20140514_seminar.html

The graduation ceremony for the academic year 2013 was held at Tokyo Gakugei University Koganei Campus on March 20th, 2014.

Two undergraduate students from our lab, Shizuka Gunji & Saori Maeda, obtained the Bachelor degree after two years of hard work!

Article Addendum

Our manuscript entitled "Class III compensation, represented by KRP2 overexpression, depends on V-ATPase activity in proliferative cells", has been accepted for publication in Plant Signaling & Behavior on 14-Nov-2013.

Our manuscript entitled "Enhanced Cell Expansion in a KRP2 Overexpressor Is Mediated by Increased V-ATPase Activity", has been accepted for publication in Plant and Cell Physiology on 15-Sep-2013.

Link: http://www.ncbi.nlm.nih.gov/pubmed/24068796

Multidimensional Exploration of Logics of Plant Development / Kick-Off Meeting will be held on 1-Oct-2013 at the Yayoi Auditorium of the University of Tokyo

Link: http://logics.plantdev.biol.s.u-tokyo.ac.jp/images/meetig/poster.jpg

Book Chapter

Regulation of PPi Levels Through the Vacuolar Membrane H+-Pyrophosphatase
Ali Ferjani, Shoji Segami, Mariko Asaoka, Masayoshi Maeshima
Progress in Botany Volume 75, 2014, pp 145-165
Editors: Ulrich Lüttge, Wolfram Beyschlag, John Cushman
ISBN: 978-3-642-38796-8 (Print) 978-3-642-38797-5 (Online)
Link: http://link.springer.com/chapter/10.1007/978-3-642-38797-5_5

The Japanese Society of Plant Morphology / HIRASE AWARD 2013

On 12-Sep-2013, the Hirase Award for Plant Morphology was presented to Dr. Ali Ferjani (Associate Professor, Tokyo Gakugei University, Department of Biology) during the 25th annual meeting of the Japanese Society of Plant Morphology, as a winning representative on behalf of his co-authors.  The "Hirase Award" was founded in 1996, on the hundred anniversary of sperm discovery of ginkgo by Hirase Sakugoro. Bearing the name in honor of the achievements of Hirase, this award is given to the excellent original paper that contributes to advances in plant morphology.
◇Awarded paper: Ferjani A, Segami S, Horiguchi G, Muto Y, Maeshima M, Tsukaya H (2011) Keep an eye on PPi: The vacuolar-type H+-pyrophosphatase regulates postgerminative development in Arabidopsis. Plant Cell 23: 2895-2908.
◇Reasons for Award:” This paper has revealed that the removal of pyrophosphate (PPi), rather than vacuolar acidification, by the vacuolar H+-pyrophosphatase is important for postgerminative development. This is an invaluable new discovery that by further elucidating its molecular mechanism is promising to open a new era in the field of plant science”.
◇The awarding ceremony and prize winning commemoration poster presentation were held at Hokkaido University on the afternoon of September 12th, 2013.
Link: http://www.u-gakugei.ac.jp/news/2013/09/-hirase-award.html

Multidimensional Exploration of Logics of Plant Development

This research project under the leadership of Hirokazu Tsukaya (The University of Tokyo, Graduate School of Science, Professor), aims to revolutionize the field of developmental biology through new concepts and a research style that is expected to produce breakthroughs for the understanding of fundamental logics of plant development.
Link: http://logics.plantdev.biol.s.u-tokyo.ac.jp/en/outline.html

Our manuscript entitled “The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development”, has been accepted for publication in Plant Physiology on 24-Apr-2013

Link: http://www.ncbi.nlm.nih.gov/pubmed/23616603

Links

  • Multidimensional Exploration of Logics of Plant Development
  • The University of Tokyo・Tsukaya Lab.
  • Rikkyou University・Horiguchi Lab.
  • Nagoya University・Maeshima Lab.
  • The Arabidopsis Information Resource (TAIR)